Systems medicine approach to personalized immunosuppressive treatment at early stage after Kidney Transplantation.

The e:KID project generates a spectrum of different data types including clinical data, gene expression data, cytokine data, epigenetics data, metabolomics data as well as data derived from HLA antibody measurements and viral load measurements. We create and manage an integrative database resource for all data generated in the consortium. In addition, MicroDiscovery is performing data analysis tasks, like machine learning and gene enrichment analysis.

Partners:

Machine learning approaches have emerged as the state-of-the-art methodology to infer predictions from large-scale data with numerous applications in science and economy. The research project aims to develop novel machine learning methods and apply these to the prediction of cancer therapy success in precision medicine. The goal of the project is to learn the sensitivity of the drug response of a biological system (cell line, patient tumors) from its molecular features and their relationships. Novel methods will develop constraints that allow better inclusion of background knowledge on biological pathways and gene-gene relationships.

MicroDiscovery is generating a new knowledge base including information obtained via text mining. We apply modern text mining alogrithm on all available data sets to enhance the predicitve models of our partners.

Partners:

The cryoPOC consortium is developing a new microfluidic platform to perform immunochromatographic assays. We are aiming at a capillary driven platform for multiplex protein analytics, with an innovative concept based on an optically transparent capillary and porous polymer materials, serving as the microfluidic carrier. The capillary will include a series of separate segments with different capture molecules and controls; together with a handheld device for fluorescence detection this platform will enable two-color detection and analysis of multiplex immunoassays directly at the point of need.

MicroDiscovery is responsible for the statistical analysis throughout the projects and develops the platform and new software designed at evalutating the capillaries.

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